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1.6 Biochemical and metabolic profiling The pathogenesis of neurodegenerative disorders generally involves a complex physiopathology that includes age-related changes, abnormal function and accumulation of brain proteins, inflammation, disruption of energy homeostasis, hormonal imbalances, metabolic imbalances, DNA damage, among other processes (Gadhave et al., 2024)

Patients should further be informed that recurrence is common and that the disease cannot be cured with current treatment

This multisensory experience drives the patient to train further and consequently to gain results from a constant and consistent training program (Maggio et al., 2019b)

on BDI and MADRS, effects favored ALC but varied among studies