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doi: 10.1007/s11102-010-0251-6 20 SchallerB

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If the liver is not functioning properly, older hormones can recirculate into the bloodstream in an even more toxic form than when they originally entered the liver

Sao Paulo Med J 134:473479 Damio CP, Rodrigues AO, Pinheiro MFMC, Cruz Filho RA, Cardoso GP, Taboada GF et al (2016) Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study