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In parallel, microarray data generated by Steiner et al., who isolated mantle cells after having used copper to lesion hair cells, showed a complicated damage response consisting of upregulation of a subset of the Wnt pathway components and target genes ( Wnt3 , Wnt7a , Wnt9a ) but downregulation of others ( Wnt9a , Axin2 , Tcf4 , Sfrp2 ) immediately after damage (Steiner et al., 2014)

That said, for some people it simply comes down to their skin not responding well to certain ingredients, which may result in an unwanted reaction to skincare products (known as irritant contact dermatitis)

10.1126/scisignal.aat9900 225 SauberanJ

The facility maintained environmentally controlled conditions (constant temperature and humidity) with an automated management system for light/dark cycles regulation (12 h:12 h)