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Replacing these vitamins and maintaining a healthy diet of folic acid and vitamin b12 often help return the homocysteine level to normal, downgrade cortisol levels to prevent shrinkage of the major parts of the brain, and even treat depression

Overall, the metabolic phenotype of KIKO mice is mild compared with the more severe phenotype of patients with FRDA, who are insulin resistant and develop impaired glucose tolerance and diabetes as a consequence of cell failure (13)