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HGF/c-Met signaling pathways are uncontrolled in human cancer via overexpression of HGF or c-Met, gene amplification, mutational activation of c-Met, down-regulation of Met-targeted miRNA, binding to other ligands, autocrine signaling, or abnormally high HGF levels

The application of micelles in drug delivery, in order to minimize drug degradation and loss, to prevent harmful side effects, and to increase drug bioavailability, is also presented

Sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing PD

All these proteins and enzymes are involved in the regulation of Ferroptosis and therefore Nrf2 is considered a key regulator of Ferroptosis (Figure 2)