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Carcinogenicidad : no se han realizado estudios formales a 2 aos

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There was also no significant difference between chlorthalidone and the three study drugs in the rate of major coronary heart disease events and all-cause mortality, suggesting that the diuretic-induced cholesterol changes are not clinically significant and do not contribute to coronary heart disease risk

Rodent studies using mitochondrial-targeted peptides exhibited lower reactive oxygen species and enhanced antioxidant enzyme activity, such as increased superoxide dismutase and glutathione peroxidase in ovarian and testicular tissue