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Glutathione synthetase deficiency is an autosomal recessive disorder that was first diagnosed in 1970 in a teenager with a slowly progressive neurologic disorder and markedly elevated excretion of 5-oxoproline in the urine, as well as a history of unexplained jaundice at birth and a history of chronic metabolic acidosis

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When to hold at a current dose If you are still experiencing moderate to severe gastrointestinal side effects at your current dose level, do not escalate

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