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doi: 10.4161/cc.26417

Lipid depletion observed in Hhex KO male mice results in part from activation of lipophagy in the inner zF To better understand the mechanisms by which HHEX protects the sterol content of the zF, we interrogated cholesterol ester uptake, lipid droplet catabolism, and de novo synthesis

In the absence of a specific antidote, early recognition, close monitoring, and judicious supportive management remain crucial

On one hand, Nrf2 activates downstream target genes to regulate iron metabolism-related genes, reducing intracellular free iron accumulation and Fenton reaction-induced oxidative damage (126130)