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Correspondingly, amongst studies on neuropathic pain, Mario Delgados team proposed in 2014 that CST, a natural analgesic component of the peripheral injury receptor system, produced by peptidergic injury receptor neurons in the DRG in response to inflammation and noxious stimuli (123), plays an essential pain suppressing role in persistent inflammatory pain

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However, it is not a stand-alone cure and should be used as an adjunctive therapy in an integrative care plan

Cytotoxic edema is partly associated with the early release of glutamate and accumulation of ions and osmotically active solutes, and with failure of the active ion pumps in the neurons and glia