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HIF-1, also known as the aryl hydrocarbon receptor nuclear translocator (ARNT), is the obligate heterodimerization partner for all HIF- subunits and is indispensable for hypoxia-mediated transcriptional responses (53, 54)

Although bilirubin levels are highly heritable and genetic variation in UGT1A1 explains a large portion of the variance, it has also been shown that enzymes involved in the production of bilirubin from hemoglobin, such as HO, may also have an effect (35)