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Malignancy: Contraindicated for individuals with active malignancy or a history of cancer due to the mitogenic potential of IGF-1 stimulation

It is commonly accepted that oxidative stress induced by excess ROS/RNS levels is detrimental to biological functions and is involved in the development of many pathological conditions, such as cardiovascular diseases, neurodegenerative diseases, aging, and cancer (30, 90, 106)