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1113 Methotrexate

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High-throughput screening campaigns against the GLP-1 receptor and other class B GPCRs consistently yielded low hit rates for small molecules, and the few hits that emerged typically showed micromolar potency, insufficient for therapeutic applications

Patients would, therefore, benefit from treatment that is tailored to their disease subgroup, as well as other possible disease biomarkers, such as antibodies against cytoplasmic muscle proteins