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This includes structural alterations in glutamatergic neurons, as well as changes in mRNA and protein expression of molecules involved in glutamate signaling (glutamate receptors, glutamate transporters, glutamate synthesizing enzymes, glutamate receptor co-agonists), although some inconsistencies have also been reported [30]

For example, compared with untreated HCC cell lines, 102 significantly upregulated circRNAs were identified in cells treated with the ferroptosis inducer SF (Liu et al., 2020)