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Elias Johansson: Funding for this work by Vstra Gtalandsregionen, Region Vsterbotten and The Swedish Heart and lung foundation

Three independent studies in humans have confirmed increased intestinal permeability in different stages of RA (i.e., pre-RA, early RA, and established RA) manifested by elevated serum levels of lipopolysaccharide (LPS), LPS-binding protein (LBP), intestinal fatty acid binding protein (I-FABP), and soluble CD14 (sCD14) [2, 3, 6]