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DHT-activated androgen receptor proteins directly regulate glutathione S-transferases 11 , functioning as important redox regulators

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In an UUO mice model, EGCG was found to attenuate renal fibrosis by inhibiting the accumulation of ECM and EMT, and this renoprotective effect might be associated with its effect of the alleviation of inflammatory responses and TGF-/Smad signaling pathway inhibition (Wang et al., 2015a)