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Neuroscience and Biobehavioral Reviews, 149 , 105168

- Intraperitoneal administration of MTX &/or VPA to mice resulted in significant increase in tissue catalase and tissue glutathione reductase with significant decrease in tumor volume, tissue MDA, tissue cholesterol and tissue TNF- compared to the group that received subcutaneous implantation of Ehrlich tumor cells (Table 2, Figure 1)

Romero-Carvajal, A

In addition, it also provides the basis for the discovery and clinical application of chemical drugs and natural compounds targeting ferroptosis to effectively treat lung cancer