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IUBMB Life 61(11):10131018 Djoko KY, Ong CL, Walker MJ, McEwan AG (2015) The role of Copper and Zinc toxicity in innate immune defense against bacterial pathogens

Because these metabolic changes usually respond to treatment with oral vitamin B 12 , low serum concentrations of vitamin B 12 in the absence of clinical symptoms should be regarded as a state of subclinical deficiency