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doi: 10.3389/fmed.2023.1215180 13 ChenL.MaY.MaX.LiuL.JvX.LiA.et al

doi: 10.1080/15548627.2022.2062887 178 XieSSDengYGuoSLLiJQZhouYCLiaoJet al

Hence, even now, and despite the knowledge that APAP can cause hepatotoxicity in overdose, and the extensive research that has been conducted on its pharmacokinetics and mechanisms of toxicity over the years, there is still no quantitative model for predicting de novo the dose level at which hepatotoxicity will occur in humans and how this will vary with metabolic activity.70 Ultimately the decision to progress the development of APAP would then come down to potential risk versus benefit

Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity