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Of note, our patient did have a background of previous scattered atrophic cicatricial alopecic plaques involving the scalp in areas of discoid lupus involvement (Figure 2)

Inflammation may itself cause demyelination, as in MS, in which leptomeningeal immune cell infiltration and compartmentalized inflammation within the subarachnoid space are tightly associated with the development of cortical lesions (Choi et al., 2018)