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In other cases, the concentration of the buffer is associated with increased pain, as occurs when phosphate is used at concentrations higher than 10 mM and pH 6 (but not at pH 7) [38] or when citrate is used at concentrations of 7.310 mM [40, 42]

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The GLP-1 receptor activation component of tirzepatide may provide some beta cell protective effects, potentially slowing the autoimmune destruction of remaining beta cells in patients with residual beta cell function