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Reconstitution of purified TH into preformed liposomes As described above for the solubilized enzyme, the hydride transfer reaction catalysed by TH is fully reversible and the direction of the reaction is dictated by the relative concentrations of the present substrates

Interestingly, venous ammonia levels significantly improved in treatment groups (but not in placebo) independently of neurocognitive changes

The complicated regimen, length of therapy, and need for multiple health professionals to administer doses at various treatment sites greatly increase the risk for errors

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