The multisystem effects of hypermobile Ehlers Danlos Syndrome The multisystem effects of hEDS include: 14 Musculoskeletal joint pain and instability, tendinopathy, weakness, reduced bone density Neurological/Neurodevelopmental proprioceptive, coordination, sensory deficits, neuralgia, Autistic Spectrum Disorder, Attention Deficit Hyperactivity Disorder Autonomic nervous system cardiac dysautonomia, Postural Orthostatic Tachycardia Syndrome (POTS), Raynauds cold hands and feet Dermatological hyperextensible skin, easy bruising, poor healing, scarring Gastrointestinal Gastric reflux, pain, slow transit, constipation, irritable bowel Cardiorespiratory Mitral valve prolapse, aneurysms, varicose veins, asthma-like symptoms due to floppy airways Mental health - Anxiety, depression Uro-genital Urinary incontinence, prolapses, painful periods Immunological Mast cell activation syndrome, rashes and sensitivities Multisystemic widespread pain, chronic fatigue and sleeping difficulties
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Despite causing an increased susceptibility to OS, G6PD deficiency may also protect against CVD, since NADPH is an essential cofactor for enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R), and G6PD deficiency or NADPH deficiency may restrain HMG-CoA R activity similarly to statins (Fig
