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Interestingly, while no VSSC wildtypes were observed in Singapore, Malaysia, Saudi Arabia, Taiwan, or PNG, these countries contained both F1534C and V1016G at intermediate frequencies (Supplementary Data 3), and these may stay as partial sweeps if neither confers a fitness advantage sufficiently large to replace the other

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46 To improve therapeutic efficacy of indomethacin, another study optimized the formulation of poly (lactic-co-glycolic acid) (PLGA) microparticles for intra-articular administration of indomethacin by adjusting the pH of the aqueous phase to 3, significantly enhanced the encapsulation efficiency (90%)