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Material design can also target cuproptosis-like pathways by addressing Gram-positive and Gram-negative differences

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For instance, USM [H]L vesicles integrate encapsulated enzymes to degrade uric acid and hydrogen peroxide, generate photothermal effects for inflammation disruption, repolarize M1 macrophages to M2 phenotypes, and reprogram metabolic/immunological pathways for gout resolution (Yang et al., 2020)