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Although IGF2 gene expression is not under GH control, the circulating levels of IGF-II are largely influenced by GH status since IGF-II (as well as IGF-I and IGFBP-3) is rapidly cleared from the circulation if not bound in the ternary complex

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A threshold for uMMA/C ratios of 1.45mol/mmol has been established for adult patients with plasma B12 concentrations in the low-normal range (i.e., 201350ng/L)