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To overcome these limitations, alternative techniques including targeted proteomics (e.g., parallel reaction monitoring, PRM) and single-cell proteomics offer higher sensitivity for quantifying low-abundance proteins and resolving PTM profiles at the cellular level, necessitating the integration of enrichment strategies such as co-immunoprecipitation coupled with mass spectrometry co-immunoprecipitation coupled with mass spectrometry (CoIP-MS)

Similar content being viewed by others Introduction Alzheimers disease (AD) is a degenerative brain disease and the most common cause of age-related dementia

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