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10.1038/nature12985 12

The authors explain that the reported wound-healing activity of TB-500 in literature may be due to its metabolite Ac-LKKTE rather than the parent form.30 Additionally, there have been some positive preclinical research outcomes for the use of TB4 for hair growth,31 neuroprotection,32 tympanic membrane perforations,33 and decreasing mortality in sepsis, but more clinical research is needed before these potential benefits can be considered applicable to humans.5 Are TB4 and TB-500 safe

Several studies have shown that METTL3 plays important regulatory roles in prostate cancer proliferation, migration, invasion, apoptosis, drug resistance androgen-induced splicing and glycolipid metabolism maintenance (125,126)