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In the CY 2025 PFS proposed rule (89 FR 61596), we solicited public comment on each of the aforementioned issues for the following sections of the rule that contained information collection requirements (ICRs)

However, NNMT can methylate NAM, converting it to MNAM

122,123,124 Mammalian CYPs are a family of heme-containing NAD(P)H-dependent monooxygenases that metabolize numerous endogenous metabolites, including fatty acids and steroids, and exogenous substrates, including carcinogens, pesticides and drugs, resulting in continuous production of ROS