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Iron-driven redox vulnerabilities and ferroptosis pathways in breast cancer Dysregulated iron metabolism is increasingly recognised as a hallmark of breast cancer, with particularly strong implications for Triple-negative breast cancer

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To quantify the amount of CO, the ratio of carboxy-haemoglobin after haemoglobin addition was measured [21]

Inhibition of the first rate-limiting enzyme of one-carbon metabolism (PHGDH) has been shown to promote cell growth arrest, a phenomenon that occurs as a result of an accumulation of intracellular reactive oxygen species (ROS) following the inhibition of glutamine metabolism