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10.1007/s11356-021-16266-3 18 DengH.LiB.ShenQ.ZhangC.KuangL.ChenR.et al (2023)

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117 Another example is that the AMPs, human -defensins, can specifically bind to fibronectin (FN) to block the adhesion and transfer of integrin 51 mediating endothelial cells to fibronectin, and block the proliferation and apoptosis of endothelial cells mediated by vascular endothelial growth factor (VEGF), that is, human -defensins inhibit tumor angiogenesis in many ways, thereby exerting its anti-cancer effect

They suggested that acquired cysteines often play a role in tumourigenesis [113], probably by contributing to tumour suppressor genes inactivation and oncogenes activation