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They regulate pathways converging on mTOR and thereby directly interfere in autophagy induction

CrossRef Comparing Artificial IntelligenceGenerated and Clinician-Created Personalized Self-Management Guidance for Patients With Knee Osteoarthritis: Blinded Observational Study Kai Du, Ao Li, Qi-Heng Zuo, Chen-Yu Zhang, Ren Guo, Ping Chen, Wei-Shuai Du, Shu-Ming Li Journal of Medical Internet Research .2025

Associated datasets are provided in Supplementary Tables 14 and 67

Notably, SHMT1 and SHMT2 (SHMT2 is a splice variant of SHMT2) function as scaffolding proteins during DNA replication to exert their regulatory effects, and are localized in the cell nucleus during the S phase along with TYMS and DHFR as part of the thymidine cycle