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Figure 3 4.3 Ectopic lipid deposition Ectopic lipid deposition represents a critical physical manifestation of systemic metabolic dysregulation, wherein lipid overflow from dysfunctional adipose tissue infiltrates and compromises non-adipose organs, thereby directly linking the pathogenesis of sarcopenia and atherosclerosis ( In skeletal muscle, elevated FFAs are esterified into IMCLs

They are cells that eventually stop multiplying, yet they don't die off like they should

Adoptive transfer studies showed that systemic autoimmune function remained intact and beta cells from hIAPP transgenic mice did not evade immune recognition by diabetogenic T cells, collectively indicating the protection from diabetes was mediated by decreased antigen presentation in the pancreas

Taken together, these findings suggest that glutathione has an important role in acetaldehyde tolerance, as a direct scavenger of acetaldehyde in the cell