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However, the liver histology of the S-100 model does not show the typical AIH changes of interface hepatitis or centrilobular necrosis, and shows granulomas, which are not a feature of AIH [109]

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84 , 85 Additionally, increased oxidative stress as a response to hypoxia in a growing tumour, is a prominent hallmark in solid tumours and is negatively correlated to cancer prognosis and patient survival, the association being directly attributed to hypoxiaregulated downstream signalling molecules, mainly hypoxia inducible factor2 (HIF2), responsible for cell cycle arrest and therapy resistance