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Transgenic expression of FGF21 in pancreatic acini reduces tissue damage, lipid accumulation, and fibrosis induced by cerulein, all of which were exacerbated in animals lacking FGF21 (221, 266)

Uptake within the tegument is facilitated by the glucose transporters found on the tegument (Skelly et al., 1994, 1998)

These findings indicate that, at certain exposure levels, these metabolites have the potential to disrupt endocrine homeostasis and increase the risk of reproductive or developmental toxicity

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