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Hypothetically, for a patient with AS who has active sacroiliitis and subclinical colitis on biopsy, a biologically rational, though untested, regimen could pair a systemic biologic (such as a TNF or IL-17A inhibitor to suppress inflammation) with a gut-focused therapy (such as a probiotic or even FMT to restore microbiota and mucosal integrity)

Root Mean Square Deviation (RMSD) During the 150 ns simulation period, the structural and dynamic characteristics of the protein-ligand complexes were examined as the backbone RMSDs

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Research involving this peptide blend continues to expand into studies examining receptor binding behavior, signaling coordination, temporal pathway activity, and molecular-level response models