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17 TMP-SMX: TMP-SMX is considered first-line therapy, as it is effective despite increasing resistance and has fewer ecologic adverse effects than seen with fluoroquinolones

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Caspase-1 is the effector component of the NLRP3 inflammasome and is activated through proximity-induced autocatalytic activation upon recruitment to the NLRP3 inflammasome

Pinnamaneni P, Kantarjian H, Jorgensen JL, Jabbour E, Pierce S, Brandt M, Wang S, Konopleva M, Kornblau S, Kadia T, DiNardo C, Pemmaraju N, Andreeff M , Estrov Z, Garcia-Manero G, Cortes J, Ravandi F