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Kannan, Y., Perez-Lloret, J., Li, Y., Entwistle, L.J., Khoury, H., Papoutsopoulou, S., Mahmood, R., Mansour, N.R

Regular IGF-1 has 70 amino acids, while Long R3 IGF-1 has 83 amino acids due to the addition of 13 amino acids on its N-terminal end

At the same time, in the lipopolysaccharide-induced acute lung injury (ALI) model in rats, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) not only enhanced the activity of antioxidant enzymes (including superoxide dismutase [SOD], catalase [CAT], and glutathione [GSH]), effectively alleviated oxidative stress, but also inhibited the inflammatory response by downregulating the expression of the pro-inflammatory transcription factor NF-B