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Rice-specific component -oryzanol ( 67 ), a mixture of ferulic acid ester and several phytosterols, is a potent DNMTi in the striatum of mice, which significantly inhibited the activity of DNMT1 (IC 50 = 3.2 M), DNMT 3A (IC 50 = 22.3 M), and DNMT 3B (maximum inhibition 57%) at least partly in an SAH-competitive manner (Figure 10)