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To overcome drug resistance and enhance its cytotoxicity, two derivatives of DOX were synthesized incorporating a sulfonamide moiety: 4-mononitrobenzenesulfonyl DOX (MNS-DOX) and 2,4-dinitrobenzenesulfonyl DOX (DNS-DOX) 94

References 1 WarenyciaMWGoodwinLRBenishinCGReiffensteinRJFrancomDMTaylorJDet al

Patients with arrhythmias, particularly atrial fibrillation, present with electrophysiological abnormalities associated with electrolyte imbalances (e.g., hypokalemia) and thyroid dysfunction (137, 138)

XH participated in supervision, resources, writing, reviewing and editing the manuscript, the overall conception and experimental design of the study, guidance and suggestions in establishing the research ideas, constructing the research framework, refining the key scientific questions and formulating the research plan