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HeLa cells were also used as a tumor cell model, and in vivo and in vitro experiments suggested that under X-ray irradiation, CeO 2 MnO 2 exerted a positive anti-tumor effect by generating massive ROS in the cells, leading to a flip in mitochondrial membrane potential and accelerating apoptosis of tumor cells (Scheme 1)

It has been previously shown that DJ-1 can suppress the aggregation and oligomerization of -synuclein, thus promoting its degradation, which is dependent on the redox state of the cell environment [119,121]

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Beneficial effect of low-dose systemic retinoid in combination with topical tretinoin for the treatment and prophylaxis of premalignant and malignant skin lesions in renal transplant recipients