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Thus, even though it is important from the point of view of client protein function that the ER retain enough reducing power to prevent protein hyperoxidation, it does not necessarily portend that an abundance of hyperoxidized proteins are sensed as a disruption to ER homeostasis as readily as an abundance of underoxidized proteins

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Resveratrol decreases the concentrations of MCP1, VEGF (150), IL-6, IL-8, and TNF in peritoneal fluid in vitro and in animal models (151), inhibiting angiogenesis and inflammation to regress endometriotic lesions (152)

This binding event leads to the internalization and subsequent degradation of ferroportin, thereby controlling the release of iron from macrophages and enterocytes into the circulation