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Additional functional gene enrichment analysis revealed that, at high altitudes, gut microbiota exhibit an increased potential for utilizing CO 2 and oxaloacetate in the synthesis of energy substrates such as acetyl coenzyme A and pyruvate, respectively, and in the conversion of acetyl coenzyme A into acetate (Zhao et al., 2023b)

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3 Discussion Lynch syndrome is a hereditary disease caused by germline mutations in mismatch repair (MMR) genes, significantly increasing the lifetime risk of colorectal, endometrial, and ovarian cancers in women

To produce and recycle it effectively, the body requires specific "cofactors"supporting nutrients that help the biological machinery run