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GSH, in a particular experimental model of monocyte-macrophages, protected against macrophage death by conjugation of HNE, thereby rendering it non-toxic, the last example of this property of GSH of neutralizing reactive intermediates that otherwise cause cellular and tissue toxicities

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Additionally, CAR-T cell therapies are hampered by severe toxicities, limited efficacy in solid tumours, resistance mechanisms in B-cell malignancies, antigen escape, inadequate persistence and trafficking, and the presence of an immunosuppressive TME [61]