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doi: 10.1006/abbi.1997.0470 225 BerendjiDKolb-BachofenVMeyerKLGrapenthinOWeberHWahnVet al

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Therefore, understanding the pathophysiology of dialysis-related fatigue and developing effective treatment strategies are critically important medical challenges

mtDNA is essential for maintaining mitochondrial function, but it is more susceptible to being damaged by ROS than nuclear DNA since it is closer to the mitochondrial ROS production site, after which mitochondrial genome stability is influenced and diseases occur