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Operationally, the workflow follows a stepwise sequence: clinical phenotype evaluation precedes whole-exome sequencing, as the former defines the diagnostic axes required for phenotype-directed variant analysis

The third is the "active clearance" of epithelial cells, which can engulf small molecules of harmful substances through phagocytosis and degrade them through lysosomes

This process drives the formation of highly dynamic biomolecular condensatesexemplified by nucleoli, RNA polymerase II condensates, stress granules, and P-bodieswhich enable spatiotemporally precise regulation of biochemical reactions through localized enrichment of reaction components, sequestration of inhibitory factors, or assembly of signaling platforms [12]

According to Rabei et al