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Clinical research on polyphenol bioavailability is advancing, but large-scale intervention trials remain scarce

10.1016/s0304-3940(01)01677-9 105 KimotoK.AokiT.ShibataY.KamisukiS.SugawaraF.KuramochiK.et al (2007)

These approaches are fundamentally different from traditional CNS drugs, as they work holistically through the gut-brain axis, potentially influencing multiple pathways (immune, metabolic, neural) simultaneously