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First-pass effect An effect in which the concentration of a drug is greatly reduced via presystemic metabolism before it reaches the systemic circulation

6H, Supplementary Fig

Similarly, in an open-label study of 69 children with organic or idiopathic GHD, r-hGH was associated with a median growth of 47.5 8.5 cm over 7 years of treatment, with most subjects reaching their predicted final height [1]