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Similarly, metallic nanoparticles (MNPs) (gold, silver, zinc oxide) are conjugated with phytoextracts like Aloe barbadensis , Leucas aspera , Pyrenacantha grandiflora , and Withania somnifera for wide therapeutic efficacy against microbial infections, ulcerative colitis, cancer, and oxidative stress by facilitating extended drug circulation, intercellular targeting, drug stabilization, and higher delivery [19, 20]

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Future clinical research on anti-angiogenic targeted drugs can focus on the following directions: First, when selecting anti-angiogenic targeted drugs, researchers should pay attention to the stage and type of GC of the patient, and continue to explore the best time for applying the drugs for specific GC