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Primary cell cultures from rodents offer a good alternative for examining the pathological impact of A and tau in cellular health and machinery but are restricted for not fully recapitulating the disease phenotype due to limited resemblance to age-related cellular immune dysfunctions [174, 175]

Moreover, by analyzing the CTCs in blood vessels of breast cancer patient tissues, we found that mitochondrial CD147/MCT1/LDHB complexes occurred in CTCs of 6 out of 10 patients (Fig