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Specifically, cardiovascular risk factors may mediate at least a part of their effects on the heart and blood vessels via hyperuricemia and the latter may exert their deleterious effects on cardiac and vascular structures via cardiovascular risk factors (notably arterial hypertension)

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357,363 In addition, there are mild signs for astrocytic reactivity mainly in cerebral neocortices

Interestingly, NMD efficiency remains reduced even when the downstream AUG lies in a different reading frame, suggesting the existence of additional, uncharacterized mechanisms underlying NMD evasion